The Free Radical Theory of Aging was first described back in the 1950s, and proposed that aging is caused by the accumulation of oxidative damage to cells from free radicals.1 Since then, the theory has evolved along with advancing science on the role of oxidative stress in cellular function and aging.2 Glutathione is a key factor in maintaining antioxidant balance and helps to protect cellular functions against damaging oxidative stress that can contribute to accelerated cellular aging.3
More recently, research has focused on how novel nutritional interventions can help to address Glutathione deficits in order to promote more effective management of oxidative stress within our cells. One thought leader in this area is Dr. Rajagopal Sekhar, who has pioneered research on supplementation of specific Glutathione precursors, and the important role this can play in supporting Glutathione synthesis and combating the accumulation of cellular oxidative damage.
Learn more about how the cellular nutrient combination of NAC & Glycine (GlyNAC) work as building blocks for “master antioxidant” Glutathione.
What Is Glutathione?
Glutathione is a powerful antioxidant naturally present in our cells.4 It helps neutralize free radicals that can contribute to oxidative damage and is important for mitochondrial health and immune function.5 Known as a “master antioxidant,” Glutathione also helps other antioxidants like vitamins C & E do their jobs.5
Where Does Glutathione Come From?
Glutathione must be made inside our cells. This unique molecule is comprised of three amino acids — cysteine, glycine, and glutamic acid. Each of these amino acids must be available in sufficient amounts for cells to produce Glutathione in response to our changing cellular needs.4
The Role of Glutathione in
Oxidative stress can be the result of multiple cellular processes. The constant creation of ATP, which is the fuel that energizes ourcells, involves a series of chemical reactions within our mitochondria — the “powerhouses” of the cell.2 These reactions generate reactive oxygen species (ROS), including free radicals, and other toxic by products.2 Accumulation of ROS can be further aggravated by environmental sources of oxidative stress, including a poor diet, sedentary lifestyle, and pollutants.3
The powerful antioxidant glutathione helps to neutralize free radicals, but cellular levels of glutathione have been shown to decrease with age.6,7 This decrease can create an imbalance between free radicals and glutathione which contributes to oxidative damage within cells.3
While our cells will not produce excess levels of glutathione, it is possible to have too little to meet our changing needs. Research has shown that aging cells often have lower amounts of the precursor amino acids, cysteine and glycine, which may limit their ability to meet the cellular demand for glutathione.6
Why Is Glutathione important as we age?
Declining levels of glutathione during aging are associated with:5,6
- Increased susceptibility to cellular damage from internal oxidative stress
- Reduced cellular protection against free radicals and other threats
- Impaired mitochondrial function
Research over the past ten years has shown that daily supplementation which provides enough of the precursor amino acids or “building blocks” for Glutathione needed to address shortfalls can help to manage oxidative stress within cells.6,7
Replenishing the Building Blocks of Glutathione
A patented combination of Glycine and N-Acetyl Cysteine (NAC), or GlyNAC for short, helps replenish key amino acids needed to support Glutathione production. Having the right levels of Glutathione to match your changing needs is important for cellular protection and normal immune function.
1. Harman D. J Gerontol. 1956;11(3):298-300. 2. Lopez-Otin C et al. Cell. 2013;153(6);1194-1217. 3. Sekhar RV et al. Encyclopedia of Gerontology and Population Aging. 2019. 4. Gould RL and Pazdro R. Nutrients. 2019;11:1056. 5. Teskey G et al. Adv Clin Chem. 2018;87:141-129. 6. Sekhar RV et al. Am J Clin Nutr. 2011;94(3):847-853. 7. Kumar P et al. Clin Transl Med. 2021;11(3)e372.
Celltrient™ Protect FAQs
A new range of supplements and nutritional beverages formulated with targeted cellular nutrients to help fight key sources of age‐associated cellular decline and promote cell health. As we age, so do our cells. Celltrient™ is designed to go deeper with targeted nutrients to help transform how cells perform with age. Traditional micro and macronutrients meet basic nutritional needs. However, they are generally not enough to combat the declines of cells' natural processes. Celltrient™ is:
-Backed by Science
-Precisely formulated to address 3 major sources of cell aging
-Made to work in harmony with the body's natural processes
-Contains cellular nutrients that go to work deep inside cells to help renew and restore cells' natural processes
Celltrient™ works with your body’s natural processes to promote cell health, cell by cell to revitalize and renew your cells’ natural processes. The product range features cellular nutrients that help replenish NAD+ important for natural energy production, renew the power plants in muscle cells and replenish essential building blocks for the protective antioxidant Glutathione.
Glutathione is a powerful antioxidant naturally present in our cells. It helps neutralize free radicals that can contribute to oxidative damage and is important for detoxification and immune function. Known as a "master antioxidant", Glutathione also helps other antioxidants like vitamins C&E do their jobs.
Celltrient Protect is made with natural flavors. These ingredients will contribute to a [fruity cranberry flavor] [citrus lemon flavor]
Glycine is one of 11 non-essential amino acids required by the body. N-Acetyl Cysteine is a derivative of Cysteine (another non-essential amino acid required by the body). Glycine and Cysteine are building blocks for Glutathione. Glutathione is an antioxidant that helps protect cells from oxidative stress.
Celltrient Cellular Protect dietary supplement drink mixes are formulated with a specialized blend of vitamins and minerals, including Vitamins C&E, Riboflavin, Zinc and Selenium, which are important for glutathione synthesis and function within cells.
One of the key amino acids in Celltrient™ Protect is N-acetyl cysteine (NAC) which is part of a family of amino acids called Sulfur Amino Acids. Some sulfur notes when you open the package is expected due to the potency of the active ingredient. The aroma should diminish after mixing.
Celltrient Protect provides building blocks that enable cells to make antioxidant Glutathione as needed in response to changing cellular conditions.† Vitamin C&E supplements provide antioxidants directly, in amounts that may not be matched with cellular needs.
Supplementing Glutathione directly is often not an effective way to increase Glutathione levels, since many forms are broken down by the body during digestion. Celltrient™ Protect helps replenish building blocks cells use to make Glutathione when it is needed.
Our Celltrient™ Protect Drink Mix also contains additional vitamins and minerals like vitamins C & E, Riboflavin, Zinc and Selenium, and offers an alternative way to consume our product if you prefer not to take pills. However, the recommended daily serving ensures that you get the same amount of our cellular nutrients, Glycine N-acetyle Cysteine (GlyNAC) to help replenish cellular building blocks for glutathione.
Traditional micro and macronutrients naturally found in foods help to meet basic nutritional needs. Cellular Nutrients may be available or derived from food sources yet are likely to be consumed in suboptimal amounts from a usual diet. For example:
‐ NAC is not found in foods. Cellular levels of Glycine and Cysteine have been shown to be reduced with age and increased exposure to oxidative stress.
GlyNAC (Glycine + N‐acetyl cysteine), found in Celltrient™ Cellular Protect, provides building blocks to help cells make the antioxidant glutathione in response to cellular needs. Clinical studies have shown that these two amino acids are less available in our cells as we age. Supplementation with Glycine and NAC can help replenish these important amino acid precursors for glutathione production.
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