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The Science Behind Celltrient Cellular Energy

Every activity we do starts with our bodies generating ATP (the specialized cellular fuel) inside our cells.

This natural process requires us to be able convert the food we eat into the energy we need. A key component of this process is a specialized molecule called NAD+ (which is short for nicotinamide adenine dinucleotide).

Tru Niagen® Nicotinamide Riboside is an advanced cellular nutrient clinically shown to boost NAD+ levels

Tru Niagen® (NR) is a unique form of vitamin B3 that is clinically shown to increase NAD+ levels in as little as 2 weeks.1 NR’s primary job is to help replenish NAD+ levels to support your cells’ natural ability to transform nutrients into energy in the form of ATP.

Image of glowing cell

What Is NAD+ and where does it come from?

NAD+ is an important molecule found inside every living cell. NAD+ plays a critical role in cellular energy production, and is also required for normal mitochondrial function, cellular stress response, and DNA repair.2

Our bodies can synthesize NAD+ from dietary precursors found in foods containing various forms of niacin (vitamin B3) or the amino acid tryptophan. These precursors differ in how efficiently they are converted to NAD+.3

NAD+ levels decline by up to 50% between the ages of 40 and 60 years. Lack of NAD+ can contribute to tiredness and fatigue.

Why is NAD+ Important As We Age?


Research has shown that NAD+ levels decline by up to 50% between the ages of 40 and 60 years. This is related to impaired NAD+ synthesis as well as increased NAD+ demand for processes like DNA repair.4,5

The decline in NAD+ as we age can lead to a decreased capacity to naturally produce cellular energy.5 This means cells need to constantly replenish NAD+ to maintain proper function.6

Although our cells can make NAD+ from precursor foods found in our diets, the body’s ability to produce enough becomes more of a challenge with age.2 Lower NAD+ levels have been observed in individuals with fatigue and in the muscle cells of older adults with sarcopenia (the age-related decline in muscle mass and function).7,8

glowing cell

Nicotinamide Riboside (NR) an advanced cellular nutrient clinically shown to boost NAD+ levels in our cells

Tru Niagen® Nicotinamide Riboside (NR) is a unique form of vitamin B3 that is clinically shown to increase NAD+ levels in as soon as 2 weeks.1 NR’s primary job is to help replenish NAD+ levels to support your cells’ natural ability to transform nutrients into energy in the form of ATP.

Image of Celltrient Energy

Celltrient Cellular Energy

Helps replenish NAD+ in a soon as 2 weeks with targeted nutrients, helping cells transform food into energy.

References

1. Conze D et al. Sci Rep. 2019;9(1):9772.      2. Katsyuba E et al. Nature Metab. 2020;2:9-31.      3. Canto C et al. Cell Metab. 2015;22(1):31-53.      4. Massudi H et al. PLoS One. 2012;7(7):e42357.      5. Clement J et al. Rejuvenation Res. 2019;22(2):121-130      6. McReynolds MR et al. Exper Gerontol. 2020;134:110888.      7. Castro-Marrero J et al. Antioxid Redox Signal. 2015;22(8):679-685.      8. Migliavacca E et al. Nat Commun. 2019;10(1):5808.

Celltrient™ FAQs

A new range of supplements and nutritional beverages formulated with targeted cellular nutrients to help fight key sources of age‐associated cellular decline and promote cell health. As we age, so do our cells. Celltrient™ is designed to go deeper with targeted nutrients to help transform how cells perform with age. Traditional micro and macronutrients meet basic nutritional needs. However, they are generally not enough to combat the declines of cells' natural processes. Celltrient™ is:

-Backed by Science

-Precisely formulated to address 3 major sources of cell aging

-Made to work in harmony with the body's natural processes

-Contains cellular nutrients that go to work deep inside cells to help renew and restore cells' natural processes

Celltrient™ works with your body’s natural processes to promote cell health, cell by cell to revitalize and renew your cells’ natural processes. The product range features cellular nutrients that help replenish NAD+ important for natural energy production, renew the power plants in muscle cells and replenish essential building blocks for the protective antioxidant Glutathione.


NAD+, or nicotinamide adenine dinucleotide, is an important molecule found in every cell in the body. NAD+ plays a critical role in cell energy production, and helps cells transform food into energy that fuels the entire body. NAD+ is also important for healthy mitochondrial function and cellular repair. Research has shown that NAD+ levels decline by up to 50% between the ages of 40 and 60 years. A shortfall of NAD+ may limit cell energy production.

Celltrient™ Energy is made with natural flavors. these ingredients will contribute to a [fruity summer cherry flavor] [citrus orange flavor]

Celltrient™ Energy was formulated to be mixed with 8 fl oz of water, but can be mixed with juice or other cold beverages, to taste.

NR is efficiently converted to NAD+ within cells, while the process to turn other forms of niacin into NAD+ can be slower or more complex. High doses of nicotinic acid can also lead to side effects like flushing. NR has been shown to be well-tolerated and to significantly increase NAD+ levels in multiple clinical trials.

Caffeine stimulates the nervous system, which produces temporary feelings of alertness and can cause jitteriness at high doses. Celltrient™ Energy is designed to avoid energy spikes with a caffeine-free formula that provides NR to support your body's ability to produce natural cellular energy.

Traditional micro and macronutrients naturally found in foods help to meet basic nutritional needs. Cellular Nutrients may be available or derived from food sources yet are likely to be consumed in suboptimal amounts from a usual diet. For example:

‐ NAC is not found in foods. Cellular levels of Glycine and Cysteine have been shown to be reduced with age and increased exposure to oxidative stress.

‐ NR is a unique form of niacin (vitamin B3) naturally found in trace amounts in milk, but is not widely found in other common sources of B vitamins.

‐ UA is a metabolite formed by gut bacteria when we eat foods containing compounds called ellagitannins – a type of polyphenol found in plants like pomegranates, berries, and nuts. However, even if you eat these foods, only 1 in 3 people have the gut bacteria needed to efficiently transform ellagitannins into UA

The cellular nutrients, GlyNAC, UA and NR, in Celltrient™ products have been studied in clinical trials. In these studies, the nutrients are taken daily over a period of weeks to several months. Based on this, we recommend that you take Celltrient™ every day.

GlyNAC (Glycine + N‐acetyl cysteine), found in Celltrient™ Cellular Protect, provides building blocks to help cells make the antioxidant glutathione in response to cellular needs. Clinical studies have shown that these two amino acids are less available in our cells as we age. Supplementation with Glycine and NAC can help replenish these important amino acid precursors for glutathione production.

Urolithin A (UA), found in Celltrient™ Cellular Strength, was evaluated in a randomized, doubleblind, placebo‐controlled trial in healthy older adults. Daily supplementation with UA for 4 weeks improved markers of mitochondrial function and increased markers of mitophagy in skeletal muscle. A second clinical trial with UA was recently completed, and showed improved hamstring muscle strength in healthy, overweight adults consming UA daily for 4 months.

Nicotinamide Riboside (NR), found in Celltrient™ Cellular Energy, has been studied in numerous clinical trials, resulting in 11 published studies. NR is clinically shown to increase NAD+ levels in as soon as 2 weeks, and these levels are sustained with continued daily intake of NR.

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